![]() ![]() T4 is then broken down to its more active form T3 by a group of enzymes called deiodinases and mainly found in the liver and kidneys. The thyroid gland produces T4 from iodine and the amino acid tyrosine. TSH, in turn, stimulates T3 and T4 production in the thyroid gland. The hypothalamus produces thyrotropin-releasing hormone (TRH), which activates the pituitary to produce and release thyroid-stimulating hormone (TSH). The production of these hormones is regulated by a system involving the hypothalamus, pituitary, and thyroid gland – the hypothalamus-pituitary-thyroid axis. It produces the thyroid hormones thyroxine (T4) and triiodothyronine (T3), which control the growth, development, and metabolism of nearly every cell in the body. The thyroid is a gland located at the base of the neck, below the Adam’s apple. How Hypothyroidism Affects the Brain The Hypothalamus-Pituitary-Thyroid (HPT) Axis Read on to learn more about the best foods, supplements, and lifestyle strategies to beat hypothyroidism-linked “brain fog.” Hypothyroidism is a hormone imbalance that may come along with a group of symptoms that can affect your cognition, mood, and energy. A plus sign next to the number “” means that the information is found within the full scientific study rather than the abstract. Note that each number in parentheses is a clickable link to peer-reviewed scientific studies. ![]() If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at Our goal is to not have a single piece of inaccurate information on this website. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists.Īll of our content is written by scientists and people with a strong science background. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. We believe that the most accurate information is found directly in the scientific source. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. ![]()
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